359MOLECULAR DOCKING AND ADMET ANALYSIS OF THE ROSEMARY PLANTCONSTITUENT WITH MULTIPLE PHARMOCOLOGICAL ACTIVITIESRosmarinus officinalis (rosemary) is a medicinal plant rich in bioactive phytochemicals with antioxidant, anti-inflammatory, cardioprotective, and anti-atherosclerotic properties. The present study aimed to evaluate the molecular interactions of ten major rosemary phytochemicals, namely carnosic acid, rosmarinic acid, carnosol, ursolic acid, oleanolic acid, rosmanol, betulinic acid, kaempferol, quercetin, and ?-sitosterol, against multiple target proteins associated with oxidative stress, inflammation, atherosclerosis, foam cell formation, endothelial dysfunction, hepatoprotective and cell proliferation using molecular docking. Docking analysis was performed using AutoDockVina, while protein-ligand interactions were visualized using Discovery Studio Visualizer. ADMET analysis was carried out using Swiss ADME and pkCSM to predict the pharmacokinetic and toxicity profiles of the selected phytochemicals. Several compounds exhibited favorable binding affinities toward proteins involved in anti-inflammatory, anti-atherosclerotic, anti-foam cell formation, endothelial protective, and anti-proliferative activities. ADMET analysis indicated that most phytochemicals possessed acceptable drug-likeness and safety profiles, although kaempferol and quercetin showed predicted AMES toxicity, and ursolic acid, rosmanol, and betulinic acid were predicted to exhibit hepatotoxicity. Overall, the findings suggest that rosemary phytochemicals possess promising therapeutic potential and may serve as lead compounds for further experimental validation in the development of natural agents for cardiovascular protection.indhunatarajan2605@gmail.comResearch1622026 Rosmarinus officinalis, Molecular docking, ADMET, Antioxidant, Anti-inflammatory, Cardioprotective, Antiatherosclerotic, Endothelial protection, Foam cell formationDr. Saravanan C1, Indhu N1Professor Cum HOD Department of Pharmaceutical Analysis, Aadhibhagawan College of Pharmacy, Rantham Village, Thiruvannamalai District-604407, Tamil Nadu, India 2B. Pharm Final Year, Aadhibhagawan College of Pharmacy, Rantham Village, Thiruvannamalai District-604407, Tamil Nadu, India