355MONOCLONAL ANTIBODIES IN MODERN THERAPIES: EVOLUTION, MECHANISMS, APPLICATIONS, FUTURE INNOVATIONS ON PRECISION MEDICINESince its invention in the 1970s, monoclonal antibody (mAb) has become a revolution in modern medicine being more precise in targeting disease-specific antigens with greater safety and efficacy in a wide variety of therapeutic indications including oncology, autoimmune, infectious, cardiovascular, and metabolic diseases. Their modes of action are antigen neutralization, immune system modulation and drug delivery. Developments in antibody technology which include bispecific antibodies, antibody-drug conjugates and nanobodies have increased the clinical use of antibodies. Even with outstanding curative outcomes, mAbshave been confronted with the problem of immunogenicity, high cost and unavailability. The barriers are expected to be overcome in the future, through mRNA-encoded antibodies, AI-driven target discovery and non-invasive techniques of delivery. Precision medicine is being established by incorporating companion diagnostics, thereby making mAbs a fundamental core. Monoclonal antibodies will become a game changer in the healthcare industry in the future with a consistent stream of innovation and regulatory backing.srid9225@gmail.comResearch1622026Monoclonal Antibodies, Targeted Therapy, Immunotherapy, Antibody Engineering, Precision MedicineDivya Sri N1*, Lahari B1, Sai Neha Sri N1, Naga Greeshma M,Dr. Pravallika VPharm. D Intern, Department of Pharmacy Practice, KLR Pharmacy College, Paloncha, Telangana, India,Assistant Professor, Department of Pharmacy Practice, KLR Pharmacy College, Paloncha, Telangana, India